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A higher expression of IL-4 and IL-13 is uncovered in the synovial fluid of early RA rather than established RA, which means IL-4 and IL-13 would be the diagnostic biomarkers for early RA patients (84, 85)

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The most common problems in those trials were gastrointestinal (nausea, diarrhoea, constipation and vomiting), along with an unusual skin-sensitivity effect