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When MTHFR activity is reduced, 5-MTHF production falls methionine regeneration is impaired homocysteine accumulates folate is increasingly sequestered as 5,10-MTHF THF availability for nucleotide synthesis falls

Its about preserving what matters muscle, function, metabolism while targeting the tissue that poses the most risk: excess adipose tissue , especially visceral fat

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Open communication with your healthcare provider is key to staying comfortable while using Retatrutide