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At this point, the conclusion was clear

Still, researchers point out that these trials involved people with established cognitive symptoms, and its possible GLP1 drugs might be more effective if given earlier, before the neurological damage is advanced

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This trial also found a trend (p=0.07) for a lower rate of disease progression with topical citicoline (91)

Martnez de Toda I, Gonzlez-Snchez M, Daz-Del Cerro E, Valera G, Carracedo J, Guerra-Prez N

It is whether you can afford not to address the weight that is contributing to increased health risks, reduced energy, and lower quality of life