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Chapter 14: Completing summary of findings tables and grading the certainty of the evidence

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In a rat model of diabetes-induced testicular dysfunction, liraglutide reduced testicular TGF- and Smad2 mRNA expression levels [26], whilst in HUVECs, liraglutide attenuated high glucose and IL-1-induced TGF- signalling (via inhibition of Smad2 phosphorylation), leading to reduced endothelial-to-mesenchymal transition (EndMT) marker expression [27]

Glutathione and Detoxification Processes Glutathione is involved in biochemical pathways that support the bodys natural detoxification processes, particularly in the liver

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