Patients who complete all four phases of treatment have significantly lower recurrence rates than those who stop after antimicrobials alone
Certain groups are more likely to experience high vitamin B12 levels, including: Individuals receiving high-dose B12 injections or supplements, especially over a prolonged period 6
It does not cause photosensitivity (unlike retinoids), does not thin the skin (unlike corticosteroids), and does not require a tolerance-building period
However, it is imperative to note that findings from animal models cannot be directly extrapolated to clinical trials in humans
Randomization and procedures In the initial treatment stage, periodontal infections in all patients were managed using oral hygiene instruction and mechanical debridement
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