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( Conclusion In conclusion, the emerging observation that some complications of diabetes are associated with an hyperactivation of RAAS has provided the pathophysiological basis to study the effects of GLP1-RA and SGLT2-i on RAAS to better explain the cardio-reno-protective effect demonstrated by the clinical trials, beyond their role on glucose control

Common Side Effects These are the most frequently reported: Nausea Vomiting Constipation Diarrhea Fatigue Headaches Dehydration Reduced appetite These symptoms are usually temporary and improve as the body adjusts

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