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It is one of the most-studied regenerative peptides in preclinical research, with documented effects across tendon, muscle, gut, and bone though every completed study is in animals or cell models

As a multi-receptor agonist, Retatrutide simultaneously targets GLP-1, GIP, and glucagon receptors, enhancing weight loss, improving glucose regulation, and supporting lipid metabolism

Mechanistically, GLP-1 agonists enhance insulin secretion after meals, slow gastric emptying, and suppress glucagon releaseall of which contribute to better glycemic control and weight management

GLP-1 receptor agonists are not recommended during pregnancy due to potential risks to the fetus