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The first is extracellular matrix biology: fibroblast culture and rat wound-chamber work from the Maquart and Simeon groups reported that GHK-Cu stimulates collagen, glycosaminoglycan and small proteoglycan synthesis while simultaneously upregulating matrix metalloproteinase-2 and its tissue inhibitors, a combined synthesis-and-turnover signature unusual among matrix-active compounds
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We previously reported that IL-13 increases intracellular 15-HpETE-PE via 15LO1 in vitro in modest molar amounts (see also Supplemental Figure 4A and ref
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Exercise for 30-45 minutes each day and a total of 150 minutes a week
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