glp-1 and brain health health: Beyond weight loss in the Ozempic era Blood Flow to Brain Function:

A 2024 study found that specific berberine metabolites (berberrubine and palmatine) directly increased GLP-1 production and glucose-stimulated secretion in cell studies and improved glucose tolerance in mice

Weight regain after discontinuation is common

Premature agingthink fine lines, uneven skin tone, loss of firmnessoften begins when collagen and elastin are degraded faster than the body can replenish them

Sci Rep (2018) 8(1):12496

I have serious concerns that these medications might have a deleterious effect on people with disordered eating and with diagnosed or undiagnosed EDs, Elizabeth Wassenaar, MS, MD, regional medical director for the Mountain and West regions at Eating Recovery Center, told Medscape Medical News

[14] However, in final tier, there is also a divergence, in that depending on the type of E3 ligase, it may not actually be causing the conjugation