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Description

6C-D), indicating transcriptional dysregulation

PMID: 9699001

Site rotation schedule Rotating injection sites prevents lipohypertrophy, a condition where repeated injections cause fatty tissue changes

These mutations alter the activity of the encoded enzymes such that instead of converting isocitrate to 2-oxoglutarate (-ketoglutarate), while also generating NADPH, the mutant IDH enzymes reduce 2-oxoglutarate (-ketoglutarate) to 2-hydroxyglutarate (2-HG) while simultaneously oxidizing NADPH to NAPD +