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The UK Medicines and Healthcare products Regulatory Agency (MHRA) clearly states that GLP-1 drugs should not be taken during pregnancy or immediately before attempting to conceive, as there is insufficient safety data to determine whether these drugs could harm the fetus
This is the same reason why oral tirzepatide requires special formulation technology to survive adult GI digestion
Some people might experience constipation instead, leading to different digestive issues
High glucose impairs retrograde axonal transport and leads to glutamate accumulation, which induces neurotoxicity
After the rules were put in place in 2023, the pass rates of GLP-1RA prescriptions significantly improved, and the rationalization of these prescriptions was also notably enhanced compared to the same period in 2022 ( p 1 or PRR 2 and 2 4 [20]
Weight-management programmes seeking to support fat utilisation alongside diet and movement
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