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Based on the sum of cited evidence it appears reasonable to suggest initiation of glutamate oxidation by transamination as the default pathway, but participation of GDH may occur in situations when an insufficient match between glutamate biosynthesis and degradation is not possible because of different rates, too long distances between biosynthesis and degradation sites, or prevailing conditions in vitro

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Brain cells have a high metabolism and are rich in fatty acids, which make them vulnerable to free radicals

A previous history of vitiligo can also make a patient more vulnerable to a drug-induced extension of their pigment loss