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Titration: There is generally no need for upward titration with B-complex vitamins as one might do with certain drugs, but if a patient is frail or known to react to injections, the provider may choose to start at a lower dose (for example 0.25-0.5 mL) and then increase to 1 mL as tolerated

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As a result, most dermatologists now consider microdermabrasion to be an outdated technique for skin lightening, preferring more advanced and targeted treatments such as chemical peels, laser therapy, or topical skincare products with proven skin lightening ingredients

Front Endocrinol (Laus)