QW, weekly
doi:10.1586/17476348.2016.1121105 Ayfer Aytemur Z, Baysak A, Ozdemir O, Kse T, Sayiner A
Li H, Radford JC, Ragusa MJ, Shea KL, McKercher SR, Zaremba JD, et al
Microneedling to improve skin texture and tone: Microneedling creates a controlled injury that triggers a wound-healing response in your skin
Highest Evidence Base: Consultation with healthcare providers who can evaluate individual circumstances and discuss FDA-approved options where appropriate
Hydroxocobalamin 1mg is the standard UK formulation, typically administered every two to three months for maintenance therapy Self-administration requires GP prescription, competency training from practice nurses, and demonstration of proper injection technique Common injection sites include the thigh (vastus lateralis) for both intramuscular and subcutaneous administration with site rotation essential Serious side effects are rare but anaphylaxis requires immediate 999 call