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References Jiang F, Wu Y, Liu Z, Hong M, Huang Y

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With living comes aging and the human condition exists in a Catch 22 of sorts

First identified in plasma several decades ago, this small peptide has since been situated at the crossroads of extracellular matrix regulation, cellular communication, and metal ion coordination

She explains that menopausal women often show an increase of antioxidant capacity as well as lower glutathione levels along with high levels of oxidative damage. According to Tennant, this rise in antioxidant capacity may be compensatorya protective response as the body ramps up defenses to counteract mounting oxidative stress.Since glutathione levels decrease while oxidative stress increases, its reasonable to consider supplementing with glutathione or NAC, alongside lifestyle interventions like exercise, diet, sleep, stress management, and possibly hormone replacement therapy, Tennant says

In general, elevated GSH can be observed in many cancers, including lung cancer, ovarian cancer, breast cancer, and head-neck cancer, and this adaptive upregulation of GSH has various effects on tumor advancement, metastasis, and drug resistance (Hu and Liu, 2020)