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Curcumin can not only reduce the production of uric acid by inhibiting the activity of XO, alleviating the symptoms of hyperuricemia and gout to a certain extent [443, 444], but also inhibit the activity of inducible nitric oxide synthase, reducing the production of NO [445, 446]

Histological analysis confirmed marked peribronchial and parenchymal immune infiltration following AA exposure, along with significant epithelial thickening - both of which were markedly reduced by melatonin treatment ( Figures 1D-F )

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