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Observed Effects in Phase 3 Clinical Trials: Notably, these observations derive from Phase 3 human clinical trials with thousands of participants

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For example, tirzepatide, a dual GLP-1/GIP agonist, has shown promising results in NASH trials

While none currently carry a specific FDA indication for fatty liver disease or NASH, their metabolic effects provide rationale for use in patients with concurrent hepatic steatosis

If you use oral contraceptives, consider using a backup method of contraception for 4 weeks after starting Zepbound and for 4 weeks after each dose increase