(Endocrinology, 2010), demonstrated a strong species-dependent effect: In rodents: High GLP-1 receptor expression in thyroid C-cells Strong cAMP signaling activation Persistent stimulation leads to tumor formation In humans and primates: Minimal or absent functional GLP-1 receptor expression in C-cells No meaningful calcitonin elevation under therapeutic exposure No observed C-cell proliferation in long-term studies Even exposure levels far exceeding clinical doses failed to reproduce rodent-like thyroid effects in primate models
Health Canada approves Egrifta press release
Because TMAO causally reduces eGFR, this could be a mediator in the causal pathway of its effects
Linda Lam, MD, MBA, an ophthalmologist with Keck Medicine of USC, who wasnt involved in the research, tells Healthline that its too early to make a definitive connection between NAION and GLP-1s
This glucose-dependent action is part of why it carries a lower risk of causing dangerously low blood sugar compared with some older diabetes medications
Mitochondria , the powerhouses of your cells, are very sensitive to oxidative stress