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Future work should include dose response and pharmacokinetic/pharmacodynamic studies, detailed chemical profiling of the extract, and comparisons with purified metabolites to define standardized, mechanism-informed regimens
Consulte con su mdico si no observa mejoras despus de 3-6 meses, experimenta efectos secundarios graves (dolor abdominal intenso, nuseas severas, signos de deshidratacin) o tiene antecedentes de carcinoma medular de tiroides
The calculation procedure can be found in Additional file 1: Fig S2
Prolonged treatment of neuroblastoma cell lines with standard chemotherapy agents, etoposide or doxorubicin showed increased levels and synthesis of GSH, increased expression of -glutamyl-cysteinyl ligase, and decreased depletion of GSH [58, 65]
Although well-established metabolic effects are observed in diabetes and obesity, the impact on body weight and dysfunctional adiposity is less marked in normoglycemic PD patients
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