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This was despite the fact that the work behind the patent, filed in 1997 and granted in 2001, demonstrated that the peptide helped to lower body weight for four weeks in type 2 diabetes patients who were obese (DiMarchi, Efendic)

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Administration of metformin increases the abundance of SCFAs-producing microbiota (described previously, see Chapter 4.3), thereby increasing the production of SCFAs

Clinical data shows a clear dose-response relationship, with higher doses producing significantly greater weight loss

Neuro Endocrinol Lett 2001;22:2514

Companies like Hims & Hers, Sesame, and Noom all started selling compounded versions of GLP-1 drugs for hundreds of dollars cheaper than branded versions