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Chondrocyte senescence (Zhu et al., 2021): Selectively removed senescent cells from human chondrocyte cultures, with implications for cartilage repair
P., Filbin, M
Phosphorylation at Y239/Y240 site enhances STAT3-driven immunosuppressive pathways (e.g., PD-L1 expression) while repressing STAT1-mediated immune surveillance, reducing CD8+T cell infiltration 43
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thereby, p53 may target pro-apoptotic genes and promote their expression
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