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This may result in severe clinical manifestations like myocardial infarction (MI) and HF [22,23,24]

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HF may cause kidney dysfunction through multiple mechanisms, including neurohormonal activation, inflammation and oxidative stress, with consequent reductions in renal perfusion and augmentation of renal venous pressure

Combined therapy targets multiple aging mechanisms simultaneously - NAD+ enhances mitochondrial function and DNA repair while glutathione neutralizes free radicals and supports detoxification