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Research has demonstrated that LONP1 specifically targets unfolded proteins in the mitochondrial matrix, and their accumulation promotes PINK1/Parkin-mediated mitophagy in a manner independent of mitochondrial depolarization [185]

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Studies focus on receptor binding affinity, activation kinetics, and phosphorylation mechanisms associated with receptor engagement

Serum leptin levels were also negatively associated with overall survival of ALS patients 4

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