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This observation likely reflects that MIA-induced OA primarily targets cartilage, whereas changes of the subchondral bone occur secondarily and can be influenced by factors such as mechanical loading, individual variability, and baseline bone status 52

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Hyaluronic Acid: Work as a moisture-binding agent to support skin hydration by helping retain moisture, improving smoothness and suppleness

Despite the knowledge gaps, antioxidant network not only protects the parasite from ROS and RNS, but also supports cellular redox-regulated processes (Figure 2)

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Remember: Less oxidative stress means a lower likelihood of developing non-cystic acne not to mention a more youthful and supple complexion overall