Pugliese N, di Tommaso L, Lleo A, et al
Megaloblastic anemia due to B12 deficiency is either caused by inadequate intake, in which case oral supplementation is sufficient, or poor absorption potentially due to a reduction in intrinsic factor. Intrinsic factor, which is synthesized by cells in the stomach, is secreted into the gastrointestinal tract to bind dietary B12 and facilitate its absorption (Wickramasinghe 2006)
This is often followed by a course of intravenous antibiotics to treat or prevent infection
There's also an extended-release formula that breaks down more slowly
Secondary outcomes included associations with the individual components of major adverse cardiovascular events (myocardial infarction, ischaemic stroke, cardiovascular mortality), heart failure, and all cause mortality
The triple-receptor approach is a huge leap beyond what semaglutide accomplishes with GLP-1 alone, providing avenues to manage weight loss and introducing considerations
