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Patients at Risk for Bleeding The elderly and patients with obesity are most affected by the increased bleeding risk when combining GLP-1R agonists with antithrombotic drugs such as aspirin, clopidogrel, or direct oral anticoagulants (DOACs)
PMID 17978154
Most striking was a 2011 study from Harvard Medical School by Rafail Kushak, Buie, and colleagues, which evaluated intestinal biopsies from 199 children and adults with autism ranging in age from 22 months to 28 years
The data isnt there to support safety, and we wont speculate
While some chronic conditions are influenced by the direct metabolic and hormonal effects of the medication, others improve due to the weight loss caused by the medication
However, it has been reported that the use of aromatase inhibitors resulted in reduced hot flushes as compared to GnRH agonist, while the adverse effect of aromatase inhibitors are usually mild and occurs more frequently with prolonged use
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