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They inhibit Nrf2 translocation into the nucleus and enhance NFB activation promoting inflammation and oxidative damage (Laforge et al., 2020)
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Legal status for research In the United States, BPC-157 is not a controlled substance and may be legally purchased and possessed for laboratory research use
Management protocols may also be targeted at slowing disease progression or preventing recurrence
The effect plateaued by week 12, suggesting either receptor saturation or compensatory downregulationa detail with protocol implications for researchers designing extended-duration studies
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