In vitro, we found that in PSCs, high ROS accumulation attributed to high glucose was associated with PSC activation, which was characterized by increased expression of -SMA, accelerated migration, and increased synthesis of ECM proteins such as collagen I, all of which were rescued by GSH treatment
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From hyperglycemia to intervertebral disc damage: Exploring diabetic-induced disc degeneration
Its fragrance-free, rinses off completely with water leaving no residue, maintains moisture, and is pH balanced protecting the skin barrier from upset
One of the consequences of excessive Ca2+ uptake by mitochondria is that mitochondrial respiration and mitochondrial membrane potential increase, leading to an increased likelihood of electron leakage and reactive oxygen species (ROS) production (197)
Progesterone administration modulates AQP4 expression and edema after traumatic brain injury in male rats