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GLP-1 medications and the associated weight loss can lead to loss of lean muscle, which reduces strength and endurance
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This third mechanism increases energy expenditure, which may explain why retatrutide shows greater weight loss in early clinical data (~2428% vs ~1621% for tirzepatide)
Solid lines indicate mean protein concentrations smoothed using locally weighted scatterplot smoothing (LOWESS) relative to the index date, and error bars represent standard errors
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