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In type 1 diabetes, where IGF-I and IGFBP-3 levels are decreased[302], substitutive rhIGF-I/IGFBP-3 therapy enhances protein[303] and glucose metabolism by controlling both endogenous glucose output and peripheral glucose uptake[304]

Oxidation: Exposure to air can cause oxidative damage to the amino acid side chains, particularly sensitive ones like methionine and cysteine

The plot provided a visual representation of the relative differences observed between the modified method and the reference protocol, along with the mean relative bias (Barr et al

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