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Mechanistically, high expression of BCAT1 reduces the NAD + /NADH ratio, increases mTORC1 activity, and promotes oxidative phosphorylation and nucleotide biosynthesis

Here, we solve the solution NMR structural models of the p53 transactivation domain in complex with the FOXO4 forkhead domain and in complex with FOXO4-DRI

And as their name would apply, one would go, "Oh, they're activated by heat." Well correct, they are activated, very robustly, by heat and we can talk about that

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