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ACE inhibitors, diuretics, and antihistamines can trigger nocturnal thirst within 2-4 hours of evening doses by either increasing fluid loss or reducing saliva production

The 2006 Ionescu paper documented that pulsatile GH secretion persists even under continuous receptor stimulation, suggesting somatotroph-intrinsic pulsatile release dynamics independent of receptor-binding temporal patterns (PMID 17018654)