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The combination is appealing because using a GHRH analogue such as CJC-1295 with a secretagogue like Ipamorelin potentially allows lower frequency dosing, better control over GH peaks/troughs, and possibly fewer side effects from GH overshoot or non-GH hormone activation
Sanz-Cuesta et al., 2020
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However, for some individuals, the pursuit of weight loss comes with unexpected side effects, such as hair loss
The most-cited theoretical concern is angiogenesis: both compounds promote new blood vessel formation, which is the intended repair mechanism but also a pathway relevant to tumor growth
