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Clinical trials have demonstrated hemoglobin A1c reductions of 1.9% to 2.4% in type 2 diabetes (SURPASS trials), and weight loss of approximately 15% to 21% after 72 weeks in patients with obesity (SURMOUNT-1)

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Strong Cas-3 and NF-B staining in the CARB group indicated increased apoptosis and inflammation, while AMH expression was markedly reduced, reflecting diminished follicular reserve