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A type 2 diabetes patient might take anywhere from 10 to 80+ units daily, adjusted based on fasting glucose readings

TABLE 1 Summary of key clinical trial designs and primary endpoints for tirzepatide

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Diabetes Care 41(2):356363 Karg MV, Bosch A, Kannenkeril D, Striepe K, Ott C, Schneider MP et al (2018) SGLT-2-inhibition with dapagliflozin reduces tissue sodium content: a randomised controlled trial

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Preclinical models indicate that the GLP-1 R system has evolved, at least in part, to regulate feeding-related motivation ( Repeated dosing is probably crucial for positive effects in depression and suicidality