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If you have the budget and want the most powerful option currently available in the UK, Mounjaro is the clear choice based on current clinical evidence

But in recent years that work has dwindled

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[5] [6] The effects of persistent high cortisol are wide-ranging and can include: Weight gain , particularly around the abdomen and face Insulin resistance and increased risk of type 2 diabetes Hypertension (high blood pressure) Osteoporosis and increased fracture risk Mood disturbances , including anxiety and depression Immune suppression , leading to increased infection susceptibility Muscle weakness and skin changes The relationship between cortisol and metabolic health is particularly significant

For example, cisplatin promotes cell cycle arrest and apoptosis by causing DNA damage and oxidative stress [468, 469]