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Curr Drug Metab 7 (7): 811-6 (2006)

Furthermore, dimerization of D2R with a GHSR1a mutant lacking constitutive activity still displayed dopamine-induced Ca 2+ mobilization, albeit considerably reduced, while two constitutively active mutants were absent in Ca 2+ mobilization, suggesting that Ca 2+ mobilization is independent of GHSR1a constitutive activity

This is essential for experiments or dosing in biological assays

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