Figure 3 Clinical translation and human data taxonomy The translation of these mechanisms into human clinical data requires a strict evidence taxonomy to avoid conflating metabolic improvements with intrinsic disease modification
Injectable: tenderness , swelling , bruising at the site, occasional mild flushing or transient fatigue
Despite the fact that people know tanning is dangerous and can lead to skin damage, skin cancer, and even death, theyre still doing itand now, potentially injecting themselves with a currently banned peptide called Melanotan II to stand in for a sun tan or amplify the suns rays for an even deeper bronze
JAMA , 325(14), 1416-1425
Eli Lilly published the results of its ATTAIN-1b trial for obesity in September 2025 7 , which compared orforglipron to placebo in more than 3,100 adults without diabetes, with a BMI of 30+ or 27-30 with an obesity-related complication including hypertension, dyslipidaemia, cardiovascular disease or obstructive sleep apnoea and a history of at least one patient-reported unsuccessful dietary effort to lose body weight, who have tried unsuccessfully to lose weight with diet alone
The question of building muscle on GLP-1 is important because the caloric deficit created by these medications can work against muscle growth