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The STEP clinical trial program demonstrated semaglutide 2.4 mg weekly produced sustained weight loss of 1522% over 68 weeks in adults with obesity, with 5065% of participants achieving 15% or greater weight reduction

Current trial protocols use once-daily dosing, but the improved bioavailability could theoretically support less frequent administration in the future

15,57 Notably, liraglutide exhibits relatively clear anti-fibrotic effects among GLP-1RAs, although statistically significant improvements in fibrosis were not observed in clinical trials

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