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Among these, compounds 53 (IC 50 = 4 nM) and 54 (IC 50 = 10 nM) exhibited high DPP-4 inhibitory activities, good efficacy, and selectivity in an oral glucose tolerance test in ICR mice (Figure 7)

CrossRef Computational approaches to predicting treatment response to obesity using neuroimaging Leonard Kozarzewski, Lukas Maurer, Anja Mhler, Joachim Spranger, Martin Weygandt Reviews in Endocrine and Metabolic Disorders.2022