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LY3298176 was characterised in vitro, using signaling and functional assays in cell lines expressing recombinant or endogenous incretin receptors, and in vivo using body weight, food intake, insulin secretion and glycemic profiles in mice

Older adults may be more vulnerable to muscle loss due to age-related sarcopenia and should work closely with healthcare professionals to implement protective strategies, including adequate protein intake, resistance exercise, and monitoring of functional capacity throughout treatment

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Rising hunger, waist growth, weight gain above about 2 lb per month, persistent heart-rate elevation, or declining strength indicate that the lower dose is not maintaining the prior response

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Evolution of laparoscopic techniques in bariatric surgery: Datawyse/Universitaire Pers Maastricht