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Reduced expression of tyrosine hydroxylase and TPH, biochemical markers of neuronal integrity, was observed after mephedrone administration, along with downregulation of dopamine D2 receptors in the striatum, indicating the presence of damaged nerve endings 48,49

This preserves the benefits of each while limiting irritation

The combination of pipetting and forcing sample volume through the micro-column in place at the distal end of a pipette tip provides enhancement of the enrichment process due to microfluidics, resulting in shorter incubation times

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