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The review maps engineering solutions to tissue-specific delivery challenges, critically appraises evidence across primary musculoskeletal indications, and identifies translational bottlenecks separating preclinical claims from clinical reality

Some patients report that tirzepatide partially counteracts steroid-induced appetite increases, though this is anecdotal rather than studied

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To mitigate risks, the authors recommend pairing GLP-1 therapy with resistance training and high-protein diets proven strategies to maintain muscle during weight loss

Finally, we outline future research directions, emphasizing the need for large-scale, multicenter randomized controlled trials with standardized outcomes to establish more robust evidence base and support broader international clinical adoption

Do not stop, restart, or change your dose without medical guidance