Thus, it should be clear that any disruption in the level of NADPH may have a profound effect upon a cells ability to deal with oxidative stress
Apr 2014;1311:102-123
Its biological activity depends on sulfur-bound amino acidsparticularly cysteine and methioninewhich form the critical thiol (-SH) groups that drive its antioxidant function
It protects brain mitochondria from oxidative stress and recycles other antioxidants, such as vitamins C and E
Similarly, beta-lactams and fluoroquinolones, the first-line antibiotics, have been found to play a significant role in the AMR burden globally 33,34
The answer may lie, in part, in the body's ability to manage severe oxidative stress, repair mitochondrial damage, and efficiently clear cellular debris