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doi: 10.1016/j.tcm.2021.12.008 2

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The article treats adherence as more consequential than timing itself, because it identifies escalation tolerance and adherence, not the hour of administration, as the variables that actually moved outcomes

17 Moreover, by interacting with ligands such as ADA, DPP4 exerts noncatalytic functions, including co-stimulating T-cell activation and promoting lymphocyte proliferation, which can be beneficial in modulating immune responses