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This effect is likely driven by the prolonged circulating half-lives of long-acting and ultra-long-acting GLP-1RAs, such as semaglutide (via fatty acid acylation) and dulaglutide (via Fc fragment fusion), which maintain sustained GLP-1 receptor stimulation and enhance intestinal motility, thereby increasing diarrhea risk

Chem Res Toxicol 1994

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GLP-1 provides powerful appetite suppression and gastric slowing

Other metabolites with VIP score 1 were GSH (Fig