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Data from the European LEOSS registry as well as other data show an additive effect of obesity, diabetes, and hypertension on the risk of mortality, which is higher in young and middle-aged patients (1855 years)
The investigation of metformin on prostate cancer is still ongoing, but with the introduction of other anti-diabetic drugs, the therapeutic possibilities with better outcomes have increased
While the vast majority of people absorb enough B12 through their regular, balanced diet, there are some patients for whom this is much more difficult
These dietary factors influence insulin sensitivity, glucose metabolism, and satiety far more powerfully than metabolic supplements
Patients commonly present with pain, tenderness, easy bruising, and progressive swelling that spares the feet, creating a characteristic "cuff" appearance at the ankles
Some patients report changes in appetite or food cravings during the transition period, though these effects are generally temporary and related to the physiological adjustments rather than withdrawal symptoms
