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The role of the BBB in the progression of ADRD is further supported by evidence showing that disrupted BBB function impairs efflux of A from the parenchyma (Wang et al., 2017

Fraternale et al., 2017), as well as conferring protection against oxidative stress caused by microbial, parasitic and viral infections such as SARS-CoV-2 that causes COVID-19 disease (Morris et al., 2013