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A few patterns in how we approach it: We listen first
If youre already on tirzepatide and doing well, you dont want to stop without a plan abrupt stops may risk rebound appetite, glucose changes, or losing the momentum you built
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Less frequent but still possible side effects include high blood pressure, low blood sugar levels and kidney problems which should all be monitored closely by a medical professional if experienced while taking this medication
SURMOUNT-4 (maintenance) showed continuation-group maintaining 21.8% total loss while withdrawal-group regained to 9.9% by week 88, the discontinuation pattern that mirrors the STEP 4 Semaglutide finding and implies sustained receptor engagement is required for sustained outcomes
All studies used balanced populations (inverse probability of treatment weighting or propensity score matching) and accounted for informative censoring (inverse probability of censoring weighting)
