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Combined Research on CJC-1295 & Ipamorelin When introduced together, CJC-1295 and Ipamorelin may influence GH regulation through distinct yet complementary pathways

Lawrence ECN, et al

Biologic therapies have transformed Crohn's disease management and include several FDA-approved options: TNF- inhibitors : Infliximab (Remicade), adalimumab (Humira), and certolizumab pegol (Cimzia) block tumor necrosis factor-alpha, a key pro-inflammatory cytokine

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They included 12 SGLT2i trials with 73,238 participants, of whom 3,065 were on a GLP-1 RA: they found that the benefits of SGLT2i on MACE were consistent regardless of background GLP-1 RA use (HR = 0.81 in patients receiving GLP-1 RA vs HR = 0.90 in those not receiving GLP-1RA) with no significant heterogeneity (p = 0.31)

Moreover, their potential as monotherapy for sequential control of MASLD warrants further investigation